Research in Dr. Charles France's lab focuses on interactions between
behavior and pharmacology and how those interactions impact the abuse
liability of drugs.
The lab's major goal is to understand how the subjective
and other abuse-related effects of drugs change as a consequence of
particular behavioral and pharmacologic histories. Behavioral procedures
developed in this laboratory permit systemic investigation of drug
dependence and withdrawal and ongoing studies examine how these
phenomena can be modified by behavioral and pharmacologic interventions.
Maguire DR, Henson C, France CP (2016) Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task. British Journal of Pharmacology, 173, 1350-1362. PMID26776751, PMC4940812
Maguire DR, France CP (2016) Interactions between cannabinoid receptor agonists and mu opioid receptor agonists in rhesus monkeys discriminating fentanyl. European Journal of Pharmacology, 784, 199-206. PMID27184925, PMC4939121
Collins GT, Abbot M, Galindo K, Rush EL, Rodriguez H, Rice KC, France CP (2016) Discriminative stimulus effects of binary drug mixtures: studies with cocaine, MDPV, and caffeine. Journal of Pharmacology and Experimental Therapeutics, 359, 1-10. PMID27493274, PMC5034708
Gerak LR, France CP (2016) Combined treatment with morphine and Δ9-tetrahydrocannabinol (THC) in rhesus monkeys: antinociceptive tolerance and withdrawal. Journal of Pharmacology and Experimental Therapeutics, 357, 357-366. PMID26937020, PMC4851324
Gerak LR, Collins GT, France CP (2016) Effects of lorcaserin on cocaine and methamphetamine self-administration and reinstatement of responding previously maintained by cocaine in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 359, 383-391. PMID27650954, PMC5118643
Minervini V, Dahal S, France CP (2017) Behavioral characterization of κ opioid receptor agonist spiradoline/cannabinoid receptor agonist CP55940 mixtures in rats. Journal of Pharmacology and Experimental Therapeutics, 360, 280-287. PMID27903642, PMC5267513