Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Brian L. Wickes, Ph.D.

P1010368

RESEARCH

Dr. Brian L. Wickes laboratory is interested in the molecular biology of differentiation in Cryptococcus neoformans and the identification and diagnosis of medically important fungi. This interest is manifested in a number of different projects that range from basic research to translational clinical studies and in some areas, extends beyond fungi into bacteria. 

Selected Publications

Vipulanandan G, Herrera M, Wiederhold NP, Li X, Mintz J, Wickes BL, Kadosh D. Dynamics of Mixed- Candida Species Biofilms in Response to Antifungals. J Dent Res. 2018 Jan;97(1):91-98. doi: 10.1177/0022034517729351. Epub 2017 Aug 29.

PMID: 28850289

Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, Bicanic TA, Casta├▒eda E, Chang YC, Chen J, Cogliati M, Dromer F, Ellis D, Filler SG, Fisher MC, Harrison TS, Holland SM, Kohno S, Kronstad JW, Lazera M, Levitz SM, Lionakis MS, May RC, Ngamskulrongroj P, Pappas PG, Perfect JR, Rickerts V, Sorrell TC, Walsh TJ, Williamson PR, Xu J, Zelazny AM, Casadevall A. The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere. 2017 Jan 11;2(1). pii: e00357-16. doi: 10.1128/mSphere.00357-16. eCollection 2017 Jan-Feb.

PMID: 28101535

Fu J, Blaylock M, Wickes CF, Welte W, Mehrtash A, Wiederhold N, Wickes BL. Development of a Candida glabrata dominant nutritional transformation marker utilizing the Aspergillus nidulans acetamidase gene (amdS). FEMS Yeast Res. 2016 May;16(3). pii: fow023. doi: 10.1093/femsyr/fow023. Epub 2016 Mar 13.

PMID: 26975388

White PL, Wiederhold NP, Loeffler J, Najvar LK, Melchers W, Herrera M, Bretagne S, Wickes B, Kirkpatrick WR, Barnes RA, Donnelly JP, Patterson TF. Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model.J Clin Microbiol. 2016 Apr;54(4):960-6. doi: 10.1128/JCM.03233-15. Epub 2016 Jan 20.

PMID: 26791366

Farmer AR, Murray CK, Driscoll IR, Wickes BL, Wiederhold N, Sutton DA, Sanders C, Mende K, Enniss B, Feig J, Ganesan A, Rini EA, Vento TJ.

J Clin Microbiol. Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics.2015 Jun;53(6):1968-75. doi: 10.1128/JCM.00410-15. Epub 2015 Apr 1.

PMID: 25832301

Romanelli AM, Fu J, Herrera ML, Wickes BL.

Mycoses. 2014 Oct;57(10):612-22. doi: 10.1111/myc.12208. Epub 2014 May 27. A universal DNA extraction and PCR amplification method for fungal rDNA sequence-based identification. PMID: 24865530 [PubMed - indexed for MEDLINE]

Kozel TR, Wickes B. Fungal diagnostics. Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a019299. doi: 10.1101/cshperspect.a019299. Review.

PMID: 24692193

Burnham CA, Frobel RA, Herrera ML, Wickes BL. Rapid ertapenem susceptibility testing and Klebsiella pneumoniae carbapenemase phenotype detection in Klebsiella pneumoniae isolates by use of automated microscopy of immobilized live bacterial cells.J Clin Microbiol. 2014 Mar;52(3):982-6. doi: 10.1128/JCM.03255-13. Epub 2014 Jan 3.

PMID: 24391202

Fu J, Morris IR, Wickes BL.

PLoS Pathog. 2013;9(5):e1003335. doi: 10.1371/journal.ppat.1003335. Epub 2013 May 2. The production of monokaryotic hyphae by Cryptococcus neoformans can be induced by high temperature arrest of the cell cycle and is independent of same-sex mating.

PMID: 23658522

Lyon GM, Abdul-Ali D, Loeffler J, White PL, Wickes B, Herrera ML, Alexander BD, Baden LR, Clancy C, Denning D, Nguyen MH, Sugrue M, Wheat LJ, Wingard JR, Donnelly JP, Barnes R, Patterson TF, Caliendo AM; AsTeC, IAAM, EAPCRI Investigators. Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis. J Clin Microbiol. 2013 Jul;51(7):2403-5. doi: 10.1128/JCM.00744-13. Epub 2013 Apr 24.

PMID: 23616459 

Professor
Microbiology, Immunology, and Molecular Genetics 

Education

Ph.D., Microbiology, Catholic University, 1992

M.S., Microbiology, Catholic University, 1984

B.S., Biology, Catholic University, 1980

Contact

Email: WICKES@UTHSCSA.EDU

Phone: (210) 567-3938

Research Profile
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