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Search Program Faculty/Research

Borries Demeler, Ph.D.

Bdemeler

RESEARCH

Dr. Borries Demeler's lab is currently working on the development of the UltraScan data analysis software package. This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. 

Currently, we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.

Selected Publications

For a full list, click here

Spectral and Hydrodynamic Analysis of West Nile Virus RNA-Protein Interactions by Multiwavelength Sedimentation Velocity in the Analytical Ultracentrifuge.
Zhang J, Pearson JZ, Gorbet GE, Cölfen H, Germann MW, Brinton MA, Demeler B
Anal Chem: 2017-01-03; 89(1); 862-870 Epub: 2016-12-15.
PMID: 27977168 LINK:

Simultaneous Identification of Spectral Properties and Sizes of Multiple Particles in Solution with Subnanometer Resolution.
Karabudak E, Brookes E, Lesnyak V, Gaponik N, Eychmüller A, Walter J, Segets D, Peukert W, Wohlleben W, Demeler B, Cölfen H
Angew Chem Int Ed Engl: 2016-09-19; 55(39); 11770-4 Epub: 2016-07-27.
PMID: 27461742 LINK:

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M
Proc Natl Acad Sci U S A: 2014-12-30; 111(52); 18625-30 Epub: 2014-12-17.
PMID: 25518861 LINK:

Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.
Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL
Nat Commun: 2014-08-28; 5(); 4751 Epub: 2014-08-28.
PMID: 25163529 LINK:

Characterization of size, anisotropy, and density heterogeneity of nanoparticles by sedimentation velocity.
Demeler B, Nguyen TL, Gorbet GE, Schirf V, Brookes EH, Mulvaney P, El-Ballouli AO, Pan J, Bakr OM, Demeler AK, Hernandez Uribe BI, Bhattarai N, Whetten RL
Anal Chem: 2014-08-05; 86(15); 7688-95 Epub: 2014-07-18.
PMID: 25010012   

Professor, Department of Biochemistry and Structural Biology

Director, Center for Analytical Ultracentrifugation of Macromolecular Assemblies

Director, Bioinformatics Core Facility

Co-Director, Center for Macromolecular Interactions

Education

Ph.D, Biophysics and Biochemistry, Oregon State University, 1992

B.S., Chemistry and Mathematics, University of Montana, 1988

Contact

Email: DEMELER@BIOCHEM.UTHSCSA.EDU

Phone: (210) 767-3332

Research Profile
Department Website