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Search Program Faculty/Research

Borries Demeler, Ph.D.

Bdemeler

RESEARCH

Dr. Borries Demeler's lab is currently working on the development of the UltraScan data analysis software package. This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. 

Currently, we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.

Selected Publications

For a full list, click here

Pierce, M., S. Marru, B. Demeler, R. Singh, and G. Gorbet. (2014)The Apache Airavata Application Programming Interface: Overview and Evaluation with the UltraScan Science Gateway.In Proceedings of the 9th Gateway Computing Environments Workshop (GCE '14). IEEE Press, Piscataway, NJ, USA, 25-29. DOI=10.1109/GCE.2014.15

Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M.Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18625-30, doi: 10.1073/pnas.1419945112.

Cockburn DW, Orlovsky NI, Foley MH, Kwiatkowski KJ, Bahr CM, Maynard M, Demeler B, Koropatkin NM.Molecular details of a starch utilization pathway in the human gut symbiont Eubacterium rectale.Mol Microbiol. 2014 Nov 11. doi: 10.1111/mmi.12859.

Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL.Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.Nat Commun. 2014 Aug 28;5:4751.

Demeler B., Nguyen TL, Gorbet GE, Schirf V, Brookes EH, Mulvaney P, El-Ballouli AO, Pan J, Bakr OM, Demeler AK, Hernandez Uribe BI, Bhattarai N, and RL Whetten.Characterization of Size, Anisotropy, and Density Heterogeneity of Nanoparticles by Sedimentation Velocity.Anal Chem. 2014 Aug 5;86(15):7688-95.

Memon S., M. Riedel, F. Janetzko, B. Demeler, G. Gorbet, S. Marru, A. Grimshaw, L. Gunathilake, Raminder Singh, N. Attig and T. Lippert.Advancements of the UltraScan scientific gateway for open standards-based cyberinfrastructures. Concurrency Computat.: Pract. Exper. (2014) Wiley. DOI: 10.1002/cpe.3251

Gorbet GT, Devlin B, Hernandez UA, Demeler K, Lindsey Z, Ganji S, Breton S, Weise-Cross L, Lafer EM, Brookes EH, Demeler, BA parametrically constrained optimization method for fitting sedimentation velocity experiments. Biophys. J. (2014, in press)

Pham JD, Demeler B, Nowick JS. Polymorphism of Oligomers of a Peptide from β-Amyloid. J Am Chem Soc. 2014 Mar 26.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Nguyen L, Bhattacharya A, Wang Z, Demeler B, Amie S, Knowlton C, Kim B, Ivanov DN, Diaz-Griffero F. Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1. Retrovirology. 2013 Nov 12;10:131.

Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. PLoS One. 2013 Jul 12;8(7):e69458.

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM. The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism. PLoS One. 2013 Jul 9;8(7):e67810.

Anzini P, Xu C, Hughes S, Magnotti E, Jiang T, Hemmingsen L, Demeler B, Conticello VP. Controlling self-assembly of a peptide-based material via metal-ion induced registry shift. J Am Chem Soc. 2013 Jul 17;135(28):10278-81.

Associate Professor

Biochemistry and Structural Biology

Education

Ph.D, Biophysics and Biochemistry, Oregon State University, 1992

B.S., Chemistry and Mathematics, University of Montana, 1988

Contact

Email: DEMELER@BIOCHEM.UTHSCSA.EDU

Phone: (210) 767-3332

Research Profile
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