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Search Program Faculty/Research

Bandana Chatterjee, Ph.D.

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RESEARCH

Dr. Bandana Chatterjee's lab studies pathways that control prostate cancer and novel approaches for managing this disease during therapy resistance. 

We are defining roles for 1) intratumoral androgen receptor (AR); 2) interplay between AR-dependent and AR-independent pathways. One immediate goal entails correlating expression of androgen biosynthetic enzymes in patient tumor samples to disease outcome. We showed that the androgen-inactivating enzyme SULT2B is expressed at markedly reduced levels in prostate cancer. 

This result is highly significant given its implication in androgen-regulated prostate cancer growth. In light of the known anti-prostate cancer activity of vitamin D, SULT2B induction by vitamin D is also intriguing. The second focus is to define a drug-mediated targeting approach that integrates inactivation of both the PI3K/AKT/mTORC1 axis and AR-mediated signaling. 

Selected Publications

Seo YK, Mirkheshti N, Song CS, Kim S, Dodds S, Ahn SC, Christy B, Mendez-Meza R, Ittmann MM, Abboud-Werner S, Chatterjee B. SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer. Mol Endocrinol. 2013 Jun;27(6):925-39.

Kim KY, Cho HJ, Yu SN, Kim SH, Yu HS, Park YM, Mirkheshti N, Kim SY, Song CS, Chatterjee B, Ahn SC. Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J Cell Biochem. 2013 May;114(5):1124-34.

Echchgadda I, Chang TH, Sabbah A, Bakri I, Ikeno Y, Hubbard GB, Chatterjee B, Bose S. Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense. BMC Cancer. 2011 Jan 28;11:43.

Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, Chatterjee B. Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol Endocrinol. 2011 Mar;25(3):433-44.

Shi L, Ko S, Kim S, Echchgadda I, Oh TS, Song CS, Chatterjee B. Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1. J Biol Chem. 2008 Dec 26;283(52):36474-85.

Professor
Molecular Medicine

Education

Ph.D., Biochemistry, University of Nebraska, 1977

M.S., Chemistry, University of Calcutta, 1973

B.S., Chemistry, University of Calcutta, 1971

Contact

Email: CHATTERJEE@UTHSCSA.EDU

Phone: (210) 567-7218

Research Profile
More Info...

Graduate Students

Nooshin Mirkheshti
Molecular Medicine (Ph.D.)