Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Alfred Fisher, M.D., Ph.D.

Alfred fisher

RESEARCH

Dr. Alfred Fisher is a physician-scientist who is both the head of an active basic-science focused research lab, and active in multiple service activities at the Audie L. Murphy Memorial VA Hospital and on the UT Health Science Center campus. 

These activities include serving as the associate director for the M.D./ Ph.D. program at UTHSCSA, and serving as the associate director for research for the San Antonio Geriatric Research, Education and Clinical Center based in the VA. 

He was recruited to UTHSCSA from the University of Pittsburgh and chose to join the much larger Biology of Aging research community at UTHSCSA because of the resources such as an NIA-funded San Antonio Nathan Shock Center, an NIA-funded Biology of Aging training grant, and a Biology of Aging focused Ph.D. training program. 

His research expertise is in clinical geriatrics and the use of the nematode, Caenorhabditis elegans in aging research. He is particularly interested in the roles of metabolism in the aging process. 

Specific projects in the lab include: (1) examining how metabolic stress alters proteasomal function and expression, (2) exploring how mitochondrial function changes during aging via non-invasive techniques, (3) determining how amino acids can impair insulin-like signaling, and (4) testing whether oxidative stress responses are controlled by both cell autonomous and non-autonomous mechanisms.

Selected Publications

Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, Matern D, Hu PJ, Fisher AL. (2013) TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013 Dec;9(12):e1004020.

Ferguson AA, Cai L, Kashyap L, Fisher AL. (2013) Improved vectors for selection of transgenic Caenorhabditis elegans. Methods Mol Biol 2013 Jan;940:87-102.

Kashyap L, Perera S, Fisher AL. (2013) Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 2012 Jan;67(1):56-65.

Cai L, Phong BL, Fisher AL, Wang Z. (2011) Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. J Biol Chem 2011 Oct;286(41):35915-35921.

Department of Medicine/Division of Geriatric Medicine

Barshop Institute

Biology of Aging and Cell Biology, Genetics, and Molecular Medicine

Education

M.D., Medicine, Cornell University Medical College, 1999

Ph.D., Cell Biology and Genetics, Cornell University Medical College, 1998

B.S., Biochemistry and Biology, Loyola Marymount University, 1991

Contact

Email: fishera2@uthscsa.edu

Phone: (210) 617-5197

Graduate Students

Phillip Webster (Ph.D.) 

Meghna Chinchankar (Ph.D.)