Alzheimer's disease: The forgetting gene
Posted by: Dr. David Weiss, Graduate Dean | Category: Of Interest | July 07, 2014
For many years, we have known that the APOE4 allele is associated with an
increased risk of Alzheimer’s Disease (AD) and it remains the leading genetic
risk today. Oddly enough, this fact has been largely neglected in pursuits of
disease mechanisms and potential therapeutics. Recent work, however, is
beginning to elucidate the role of APOE and may lead to an increased
understanding of the underlying mechanism of AD, and hopefully, the
identification of a potentially powerful therapeutic target. Besides the
fascinating science, this is an interesting story on persistence by some
investigators, as well as the pitfalls of biases in research for others. Read more here.
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