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Alzheimer's disease: The forgetting gene

Posted by: Dr. David Weiss, Graduate Dean | Category: Of Interest | July 07, 2014

For many years, we have known that the APOE4 allele is associated with an increased risk of Alzheimer’s Disease (AD) and it remains the leading genetic risk today. Oddly enough, this fact has been largely neglected in pursuits of disease mechanisms and potential therapeutics. Recent work, however, is beginning to elucidate the role of APOE and may lead to an increased understanding of the underlying mechanism of AD, and hopefully, the identification of a potentially powerful therapeutic target. Besides the fascinating science, this is an interesting story on persistence by some investigators, as well as the pitfalls of biases in research for others. Read more here.

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